The Gemini Virus

The Gemini Virus Author Wil Mara
ISBN-10 9781429987615
Release 2012-10-02
Pages 304
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This science-based thriller from Wil Mara will chill you to your core Bob Easton thinks he has a cold. Before he dies in agony, four days later, he infects dozens of people. Local health agencies become quickly overwhelmed by the sick and dying and beg the CDC for help. Dr. Michael Beck and Cara Porter, a member of the Epidemic Intelligence Service, race to identify the deadly bug. They can't cure it until they know what it is. Dennis and Andi Jensen and their children are terrified. Schools and offices close. Fresh food disappears from store shelves. Three of their children's friends die. Their neighbors are dying or running away, fleeing the unstoppable infection. Desperate, the Jensens join the exodus, making a nightmarish journey to their isolated mountain cabin along empty roads, through abandoned towns, past looted shopping malls. The superbug—and the panic—quickly spreads beyond America's borders. On a packed plane, someone coughs—and at their destination, the pilots are told, "you can't land here." US military bases are quarantined. Yet the virus continues to spread. Some believe the plague is man-made. Others see it as a sign of the end times. In the lab, Cara Porter makes a potentially fatal mistake. In the mountains, Andi Jensen tells her husband that she doesn't feel well. The world is running out of time. "Irwin Allen's disaster films meet Stephen King's The Stand. A scary notion."—Booklist "A chilling and horrific outbreak story. If you're a fan of Outbreak, The Hot Zone, and Contagion (the movie), you'll love Gemini Virus."—No More Grumpy Bookseller At the Publisher's request, this title is being sold without Digital Rights Management Software (DRM) applied.



The Gemini Virus

The Gemini Virus Author Wil Mara
ISBN-10 0765363933
Release 2013-08-27
Pages 368
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In the wake of a pandemic virus that rapidly spreads throughout the world killing millions of people, Dennis and Andi Jensen flee the ensuing panic and escape to the mountains while scientist Cara Porter makes a potentially fatal mistake in her laboratory. By the author of Wave. 12,500 first printing.



The Gemini Virus

The Gemini Virus Author Wil Mara
ISBN-10 9780765324313
Release 2012-10-02
Pages 301
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In the wake of a pandemic virus that rapidly spreads throughout the world killing millions of people, Dennis and Andi Jensen flee the ensuing panic and escape to the mountains while scientist Cara Porter makes a potentially fatal mistake in her laboratory. By the author of Wave. 12,500 first printing.



The Gemini Virus

The Gemini Virus Author Mara, Wil
ISBN-10
Release 2012-10-02
Pages
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The Gemini Virus has been writing in one form or another for most of life. You can find so many inspiration from The Gemini Virus also informative, and entertaining. Click DOWNLOAD or Read Online button to get full The Gemini Virus book for free.



A Novel Arabidopsis Thaliana Acetyltransferase Has a Role in Geminivirus Replication and Movement

A Novel Arabidopsis Thaliana Acetyltransferase Has a Role in Geminivirus Replication and Movement Author Roisin Carrie McGarry
ISBN-10 0496619969
Release 2004
Pages 142
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Protein acetylation is important in regulating DNA-templated processes specifically and protein-protein interactions more generally in eukaryotes. The geminivirus nuclear shuttle protein (NSP) is essential for virus movement, shuttling the viral DNA genome between the nucleus and the cytoplasm. Using NSP as a tool to investigate plant intracellular communication, a novel Arabidopsis thaliana protein that interacts with NSP, the nuclear shuttle interacting protein (AtNSI), was identified. AtNSI is highly conserved among widely divergent plants. Biochemical studies show that the interaction between AtNSI and NSP is direct and that AtNSI acetylates histones, but not NSP, in vitro. Rather, AtNSI specifically acetylates the viral coat protein in vitro. AtNSI is a nuclearprotein but does not act as a transcriptional coactivator in vitro, which distinguishes it from known eukaryotic histone acetyltransferases. The efficiency of infection by cabbage leaf curl virus is enhanced on transgenic A. thaliana that over-express AtNSI. Conversely, cabbage leaf curl virus infection on AtNSI loss-of-function mutants is delayed in the onset and spread of viral symptoms and disease characteristics are attenuated compared with infected wild type A. thaliana. These findings suggest a role for protein acetylation in coordinating replication of the viral DNA genome with its export from the nucleus. Implications for AtNSI activity in the absence of viral infection are suggested based upon interactions with two novel A. thaliana proteins, AtN & barbelow;SI a & barbelow;ssociated f & barbelow;actors 1 and 2 (AtNAF1 and AtNAF2). Future research characterizing these molecules will aid in elucidating AtNSI functions in plant growth and development.



The Whitefly Bemisia tabaci Homoptera Aleyrodidae Interaction with Geminivirus Infected Host Plants

The Whitefly  Bemisia tabaci  Homoptera  Aleyrodidae  Interaction with Geminivirus Infected Host Plants Author Winston M.O. Thompson
ISBN-10 9400715242
Release 2011-07-04
Pages 396
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The book presents a chronology of events of B. tabaci and geminiviruses, and an overview within the Caribbean and Latin America. The pathosystems involving Tomato yellow leaf curl virus, Cotton leaf curl virus and the cassava mosaic viruses are discussed. Data is presented on amino acid concentrations influencing B. tabaci and thus serves the basis for holidic diets. The essential molecular techniques for B. tabaci identification and classification are included with factors to consider for appropriate applications; an essential working guide for graduate students and researchers in the molecular field. Excellent photos portray symptoms of geminivirus-infecting crops: tomato, cotton, cassava, legumes and cucurbits; an important guide for researchers and growers. The novel insecticides, their mode of action and specificity; emphasize the applications of these within IPM programs.



Weeds as an Alternate Host of Geminivirus

Weeds as an Alternate Host of Geminivirus Author Rajneesh Prajapat
ISBN-10 1629484199
Release 2013-01-01
Pages 212
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The book represents basic information about viral-caused and viral-like diseases in many weeds. Many scientific reports have demonstrated that weeds serve as a reservoir or alternative hosts for geminivirus genera (e.g., Begomovirus) for survival and spread in the absence of main crops. This book represents a tip of the iceberg of the diversity of begomoviruses in weeds. The recognition that geminivirus strains are capable of rapidly diverging through multiple mechanisms, underscores the need for accurate molecularly based methods that permit detection and tracking of biologically significant variants. Molecular approaches must combine knowledge of biology, ecology and the ability to monitor both conserved sequences and specific sites, most likely to undergo alteration with phylogenetic predictions to facilitate accurate identification and tracking of begomovirus variants and to also recognize new or resurgent viruses. Establishing databases of baseline sequences for extant viruses will permit future comparisons in establishing and interpreting disease patterns and associated trends for vector populations. With the development of reliable computational recombination detection tools and an increasing number of available genome sequences, many studies have reported evidence of recombination in a wide range of virus genera. The book also focuses on the first geminivirus database (GVDB) that contains biotic, molecular and in silico information which will permit rapid and accurate begomovirus identification and the selection of relevant viral species for the development of disease resistance/management strategy to the geminiviruses specific to individual crop production areas. To close, there is one chapter on the international and national status of geminivirus infection in various host weeds. Furthermore, the book's heart discusses the most recent cutting-edge of research that makes this book essential reading for everyone, from researchers to scholars to students, working with molecular and computational aspects of geminivirus research as well as scientists already familiar with the area.



Transcriptional Profiling of Geminivirus Infection in Arabidopsis Thaliana Col 0

Transcriptional Profiling of Geminivirus Infection in Arabidopsis Thaliana Col 0 Author
ISBN-10 OCLC:656420933
Release 2004
Pages
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Geminiviruses are small DNA viruses that replicate in the nucleus and use plant replication machinery to amplify their single-stranded genomes. Geminiviruses replicate through a combination of rolling-circle and recombination-dependent replication. Earlier studies showed that the geminivirus, Cabbage leaf curl virus (CaLCuV), induces transcription of a host gene encoding a replication factor. To scrutinize the global impact of geminivirus infection on host gene expression, Arabidopsis transcriptome in response to CaLCuV infection at 12 days post inoculation was examined. These experiments uncovered 5241 Arabidopsis genes with changes in transcript levels (q



The Plant Cell Cycle

The Plant Cell Cycle Author Dirk Inzé
ISBN-10 0792366786
Release 2000-11-30
Pages 244
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In recent years, the study of the plant cell cycle has become of major interest, not only to scientists working on cell division sensu strictu , but also to scientists dealing with plant hormones, development and environmental effects on growth. The book The Plant Cell Cycle is a very timely contribution to this exploding field. Outstanding contributors reviewed, not only knowledge on the most important classes of cell cycle regulators, but also summarized the various processes in which cell cycle control plays a pivotal role. The central role of the cell cycle makes this book an absolute must for plant molecular biologists.



Geminivirus Induced Gene Silencing of the Arabidopsis RETINOBLASTOMA RELATED

Geminivirus Induced Gene Silencing of the Arabidopsis RETINOBLASTOMA RELATED Author
ISBN-10 OCLC:656418778
Release 2004
Pages
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My studies used the geminivirus Cabbage leaf curl virus (CaLCuV) as a vector for viral-induced gene silencing (VIGS) of the RETINOBLASTOMA-RELATED (RBR) gene in Arabidopsis. Previous results showed that RBR is a key component of the cell cycle that controls entry into S-phase by inhibiting E2F transcription factors. Hyperphosphorylation of RBR by a cyclin-dependant kinase (CDK)/cyclin complex releases E2F which then upregulates genes required for DNA synthesis. Although RBR is constitutively expressed, even in non-dividing tissues, null mutations in RBR cause gametophytic lethality, and thus make VIGS an intriguing genetic approach. Using CaLCuV vectors to silence RBR in Arabidopsis we found a reduction of leaf expansion, a proliferation of meristem-like structures, and clusters of epidermal cell outgrowths. a significant reduction in leaf size and an increase in cell density, manifested as rounded clusters of unexpanded cells on the surface of leaves. There was an increase in meristem-like structures that retained some expression of the meristem-patterning gene, WUSCHEL. Stomata were frequently found within clusters of small cells and there was evidence for an extra cell division in some guard cells. Expression of PCNA, an S-phase gene, increased in RBR-downregulated leaves, but expression of the G2/M gene, CYCB2;2, was reduced. The proportion of nuclei with 2C DNA content decreased ~2-fold suggesting that loss of RBR expression facilitated entry into S-phase. There was a corresponding increase in 4C nuclei, but higher ploidy levels were unchanged compared to empty vector controls. These results support a model in which cells continue to divide when RBR expression is reduced, even after acquiring characteristics of terminally differentiated cells, and suggest that RBR is needed for cell cycle exit. In addition I have worked towards adapting our VIGS system to be used in a large-scale capacity consistent with the goals of functional genomics. To reach this goal we u.



Plant Resistance to Viruses

Plant Resistance to Viruses Author CIBA Foundation Symposium
ISBN-10 9780470513576
Release 2008-04-30
Pages 226
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Concern about the environmental consequences of the widespread use of pesticides has increased, and evidence of pesticide-resistant virus vectors have continued to emerge. This volume presents a timely survey of the mechanisms of plant resistance and examines current developments in breeding for resistance, with particular emphasis on advances in genetic engineering which allow for the incorporation of viral genetic material into plants. Discusses the mechanisms of innate resistance in strains of tobacco, tomato, and cowpea; various aspects of induced resistance, including the characterization and roles of the pathogenesis-related proteins; antiviral substances and their comparison with interferon; and cross-protection between plant virus strains. Also presents several papers which evaluate the status of genetic engineering as it relates to breeding resistant plants. Among these are discussions of the potential use of plant viruses as gene vectors, gene coding for viral coat protein, satellite RNA, and antisense RNA, and practical issues such as the durability of resistant crop plants in the field.



DNA Replication in Eukaryotic Cells

DNA Replication in Eukaryotic Cells Author Melvin L. DePamphilis
ISBN-10 0879694599
Release 1996-01-01
Pages 1058
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National Institutes of Health. Cold Spring Harbor Monograph, Volume 31 Extensive text on the replication of DNA, specifically in eukaryotic cells, for researchers. 68 contributors, 54 U.S.



Plant Virus Host Interaction

Plant Virus Host Interaction Author R.K. Gaur
ISBN-10 9780124115989
Release 2013-12-07
Pages 430
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Plant Virus-Host Interaction contains cutting-edge research in plant molecular virology, including pathogenic viroids and transport by insect vectors, interference with transmission to control viruses, and synergism, with pivotal coverage of RNA silencing and the counter-defensive strategies used by viruses to overcome the silencing response in plants. With a clear focus on plant virus evolution, including quantitative and population genetics, Plant Virus-Host Interaction provides insights on the major factors favoring disease emergence, such as genetic change in pathogen and host populations and changes in host ecology and environment. The book also examines socioeconomic implications of widespread plant viral agents. Contributions from leading experts around the globe provide varied perspectives, while comprehensive coverage ensures a complete look at this exciting field. Covers the emergence of new viral diseases Provides molecular approaches for virus-host interaction Highlights RNA silencing and counter-defensive strategies Discusses socioeconomic implications of viral spread and mitigation techniques



Tomato Yellow Leaf Curl Virus Disease

Tomato Yellow Leaf Curl Virus Disease Author Henryk Czosnek
ISBN-10 9781402047695
Release 2007-09-23
Pages 448
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Ideally suited to horticulturalists and plant virologists, this highly useful text offers a multidisciplinary view on one of the major diseases of tomato crops, the tomato yellow leaf curl disease. It deals with epidemiological aspects of the disease as well as integrated pest management in the field. Coverage discusses the efforts aimed at breeding tomato plants resistant to the virus by classical breeding, by marker-assisted breeding and by genetic engineering.



The Papillomaviruses

The Papillomaviruses Author Robert Garcea
ISBN-10 9780387365237
Release 2007-08-19
Pages 419
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This volume evaluates the carcinogenic risk to humans posed by infection with human papillomaviruses (HPVs). To date, more than 70 HPV types have been identified, of which over 15 have been reported in cervical cancer biopsies. Worldwide, cervical cancer is the second most common cancer in women. This book also considers the possible involvement of HPV infection in cancers at other sites of the human body.



Plant Microbe Interactions

Plant Microbe Interactions Author B.B. Biswas
ISBN-10 0306456788
Release 1998-04-30
Pages 440
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Recent years have seen tremendous progress in unraveling the molecular basis of different plant-microbe interactions. Knowledge has accumulated on the mecha nisms of the microbial infection of plants, which can lead to either disease or resistance. The mechanisms developed by plants to interact with microbes, whether viruses, bacteria, or fungi, involve events that can lead to symbiotic association or to disease or tumor formation. Cell death caused by pathogen infection has been of great interest for many years because of its association with plant resistance. There appear to be two types of plant cell death associated with pathogen infection, a rapid hypersensitive cell death localized at the site of infection during an incompatible interaction between a resistant plant and an avirulent pathogen, and a slow, normosensitive plant cell death that spreads beyond the site of infection during some compatible interactions involving a susceptible plant and a virulent, necrogenic pathogen. Plants possess a number of defense mechanisms against infection, such as (i) production of phytoalexin, (ii) formation of hydrolases, (iii) accumulation of hydroxyproline-rich glycoprotein and lignin deposition, (iv) production of pathogen-related proteins, (v) produc tion of oligosaccharides, jasmonic acid, and various other phenolic substances, and (vi) production of toxin-metabolizing enzymes. Based on these observations, insertion of a single suitable gene in a particular plant has yielded promising results in imparting resistance against specific infection or disease. It appears that a signal received after microbe infection triggers different signal transduction pathways.



Molecular Biology

Molecular Biology Author
ISBN-10 0080551769
Release 1996-10-02
Pages 126
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Methods in Plant Biochemistry is an authoritative reference on current techniques in the various fields of plant biochemical research. Under the expert guidance of guest editors, each volume provides comprehensive, practical information on the assay and analytical techniques appropriate for a particular family of plant compounds. The series emphasizes techniques and laboratory procedures. No plant biochemical laboratory can afford to be without this comprehensive and up-to-date reference.